Details

Autor(en) / Beteiligte

• Whelan, Karley
• Dillon, Mairead
• Strickland, Kyle C.
• Pothuri, Bhavana
• Bae-Jump, Victoria
• Borden, Lindsay E.
• Thaker, Premal H.
• Haight, Paulina
• Arend, Rebecca C.
• Ko, Emily
• Jackson, Amanda L.
• Corr, Bradley R.
• Ayoola-Adeola, Martins
• Wright, Jason D.
• Podwika, Sarah
• Smitherman, Carson
• Thomas, Samantha
• Lightfoot, Michelle
• Newton, Meredith
• Washington, Christina
• Mullen, Mary
• Cosgrove, Casey
• Harsono, Alfonsus Adrian Hadikusumo
• Powell, Kristina
• Herzog, Thomas J.
• Salani, Ritu
• Alvarez Secord, Angeles

Titel

TP53 mutation and abnormal p53 expression in endometrial cancer: Associations with race and outcomes

Ist Teil von

• Gynecologic oncology, 2023-11, Vol.178, p.44-53

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• This multi-center cohort study assessed associations between race, TP53 mutations, p53 expression, and histology to investigate racial survival disparities in endometrial cancer (EC). Black and White patients with advanced or recurrent EC with Next Generation Sequencing data in the Endometrial Cancer Molecularly Targeted Therapy Consortium database were identified. Clinicopathologic and treatment variables were summarized by race and compared. Overall survival (OS) and progression-free survival (PFS) among all patients were estimated by the Kaplan-Meier method. Cox proportional hazards models estimated the association between race, TP53 status, p53 expression, histology, and survival outcomes. Black patients were more likely than White patients to have TP53-mutated (N = 727, 71.7% vs 49.7%, p < 0.001) and p53-abnormal (N = 362, 71.1% vs 53.2%, p = 0.003) EC. Patients with TP53-mutated EC had worse PFS (HR 2.73 (95% CI 1.88–3.97)) and OS (HR 2.20 (95% CI 1.77–2.74)) compared to those with TP53-wildtype EC. Patients with p53-abnormal EC had worse PFS (HR 2.01 (95% CI 1.22–3.32)) and OS (HR 1.61 (95% CI 1.18–2.19)) compared to those with p53-wildtype EC. After adjusting for TP53 mutation and p53 expression, race was not associated with survival outcomes. The most frequent TP53 variants were at nucleotide positions R273 (n = 54), R248 (n = 38), and R175 (n = 23), rates of which did not differ by race. Black patients are more likely to have TP53-mutated and p53-abnormal EC, which are associated with worse survival outcomes than TP53- and p53-wildtype EC. The higher frequency of these subtypes among Black patients may contribute to survival disparities. •Black patients are more likely to have TP53-mutated and p53-abnormal EC compared to White patients.•Patients with TP53-mut and p53-abn EC have a 2.2 and 1.6-fold greater risk of death than those with TP53- and p53-wt EC.•White and Black patients with TP53-mutated and p53-abnormal EC have similar progression-free and overall survival outcomes.•Concordance between TP53 NGS and p53 expression IHC tumor testing was 84.3%.