Details

Autor(en) / Beteiligte

• Sedlmayr, Viktor
• Horn, Christina
• Wurm, David Johannes
• Spadiut, Oliver
• Quehenberger, Julian

Titel

Archaeosomes facilitate storage and oral delivery of cannabidiol

Ist Teil von

• International journal of pharmaceutics, 2023-10, Vol.645, p.123434-123434, Article 123434

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• [Display omitted] •Oral CBD administration is currently limited by a bioavailability of only 6%.•Lecithin-based liposomes have limitations regarding stability.•Archaeosomes enable 6-fold increased payload compared to liposomes.•Lyophilization allows storage of CBD archaeosomes for over six months.•Accelerated and enhanced in vitro particle uptake of archaeosomes in Caco-2 cells. Cannabidiol (CBD) has received great scientific interest due to its numerous therapeutic applications. Degradation in the gastrointestinal (GI) tract, first-pass metabolism, and low water solubility restrain bioavailability of CBD to only 6% in current oral administration. Lipid-based nanocarriers are delivery systems that may enhance accessibility and solubility of hydrophobic payloads, such as CBD. Conventional lecithin-derived liposomes, however, have limitations regarding stability in the GI tract and long-term storage. Ether lipid-based archaeosomes may have the potential to overcome these problems due to chemical and structural uniqueness. In this study, we compared lecithin-derived liposomes with archaeosomes in their applicability as an oral delivery system of CBD. We evaluated drug load, storage stability, stability in a simulated GI tract, and in vitro particle uptake in Caco-2 cells. Loading capacity was 6-fold higher in archaeosomes than conventional liposomes while providing a stable formulation over six months after lyophilization. In a simulated GI tract, CBD recovery in archaeosomes was 57 ± 3% compared to only 34 ± 1% in conventional liposomes and particle uptake in Caco-2 cells was enhanced up to 6-fold. Our results demonstrate that archaeosomes present an interesting solution to tackle current issues of oral CBD formulations due to improved stability and endocytosis.