Details

Autor(en) / Beteiligte

• Chen, Xiao-Hui
• Lhazom, Tsesong
• Cui, Hai-Lei

Titel

NH4OAc/DMSO-Promoted Benzylation of Pyrrolo[2,1‑a]isoquinolines

Ist Teil von

• Journal of organic chemistry, 2023-10, Vol.88 (19), p.13598-13609

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Benzylation of pyrrolo­[2,1-a]­isoquinoline derivatives has been realized with various phenols by the use of ammonium acetate as a promoter (20 examples, up to 84% yield). DMSO served as the source of methylene and solvent. The employment of iron chloride as a catalyst can also afford the desired benzylated products in moderate to good yields (11 examples, up to a 74% yield).