Details

Autor(en) / Beteiligte

• Bhat, Basharat Ahmad
• Saifi, Ifra
• Khamjan, Nizar A.
• Hamdani, Syed Suhail
• Algaissi, Abdullah
• Rashid, Safeena
• Alshehri, Mohammed M.
• Ganie, Showkat Ahmad
• Lohani, Mohtashim
• Abdelwahab, Siddig Ibrahim
• Dar, Sajad Ahmad

Titel

Exploring the tumor immune microenvironment in ovarian cancer: a way-out to the therapeutic roadmap

Ist Teil von

• Expert opinion on therapeutic targets, 2023-09, Vol.27 (9), p.841-860

Erscheinungsjahr

2023

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Despite cancer treatment strides, mortality due to ovarian cancer remains high globally. While immunotherapy has proven effective in treating cancers with low cure rates, it has limitations. Growing evidence suggests that both tumoral and non-tumoral components of the tumor immune microenvironment (TIME) play a significant role in cancer growth. Therefore, developing novel and focused therapy for ovarian cancer is critical. Studies indicate that TIME is involved in developing ovarian cancer, particularly genome-, transcriptome-, and proteome-wide studies. As a result, TIME may present a prospective therapeutic target for ovarian cancer patients.INTRODUCTIONDespite cancer treatment strides, mortality due to ovarian cancer remains high globally. While immunotherapy has proven effective in treating cancers with low cure rates, it has limitations. Growing evidence suggests that both tumoral and non-tumoral components of the tumor immune microenvironment (TIME) play a significant role in cancer growth. Therefore, developing novel and focused therapy for ovarian cancer is critical. Studies indicate that TIME is involved in developing ovarian cancer, particularly genome-, transcriptome-, and proteome-wide studies. As a result, TIME may present a prospective therapeutic target for ovarian cancer patients.We examined several TIME-targeting medicines and the connection between TIME and ovarian cancer. The key protagonists and events in the TIME and therapeutic strategies that explicitly target these events in ovarian cancer are discussed.AREAS COVEREDWe examined several TIME-targeting medicines and the connection between TIME and ovarian cancer. The key protagonists and events in the TIME and therapeutic strategies that explicitly target these events in ovarian cancer are discussed.We highlighted various targeted therapies against TIME in ovarian cancer, including anti-angiogenesis therapies and immune checkpoint inhibitors. While these therapies are in their infancy, they have shown promise in controlling ovarian cancer progression. The use of 'omics' technology is helping in better understanding of TIME in ovarian cancer and potentially identifying new therapeutic targets. TIME-targeted strategies could account for an additional treatment strategy when treating ovarian cancer.Tumor microenvironment (TME) is made up of stromal cells, cancer cells, nerve fibers, extracellular matrix, and related cellular components. Cancer cells reside in TME, which acts as a link between the disease and the body as a whole. The immune system, the metabolism, the metabolic microenvironment, and the acidic niche are the four specialized microenvironments that make up TME.EXPERT OPINIONWe highlighted various targeted therapies against TIME in ovarian cancer, including anti-angiogenesis therapies and immune checkpoint inhibitors. While these therapies are in their infancy, they have shown promise in controlling ovarian cancer progression. The use of 'omics' technology is helping in better understanding of TIME in ovarian cancer and potentially identifying new therapeutic targets. TIME-targeted strategies could account for an additional treatment strategy when treating ovarian cancer.Tumor microenvironment (TME) is made up of stromal cells, cancer cells, nerve fibers, extracellular matrix, and related cellular components. Cancer cells reside in TME, which acts as a link between the disease and the body as a whole. The immune system, the metabolism, the metabolic microenvironment, and the acidic niche are the four specialized microenvironments that make up TME.