Details

Autor(en) / Beteiligte

• Al-kuraishy, Haydar M.
• Jabir, Majid S.
• Al-Gareeb, Ali I.
• Albuhadily, Ali K.

Titel

The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways

Ist Teil von

• Ageing research reviews, 2023-11, Vol.91, p.102075-102075, Article 102075

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Parkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be increasing, reduced or unaffected. PRL level is dysregulated in different neurodegenerative disorders including PD. Preclinical and clinical studies pointed out that PRL may has a neuroprotective against PD neuropathology . Though, the mechanistic role of PRL in PD is not fully elucidated. Therefore, the objective of the present review was to clarify the potential role and mechanistic pathway of PRL in PD neuropathology. The present review highlighted that PRL appears to have a neuroprotective effect against PD neuropathology by inhibiting the expression of pro-inflammatory signaling pathways, antioxidant effects and by inhibiting neuroinflammation. Thus, preclinical and clinical studies are warranted in this regard. •PD is a progressive NDD of the brain characterized by motors symptoms.•PRL is augmented in diverse neurodegenerative disorders.•Preclinical and clinical studies pointed out that PRL has a neuroprotective against PD neuropathology.•PRL has effect against PD neuropathology by inhibiting the expression of NF-κB and NLRP3.