Details

Autor(en) / Beteiligte

• Rahman, S. T.
• Waterhouse, M.
• Pham, H.
• Duarte Romero, B.
• Baxter, C.
• McLeod, D. S. A.
• English, D. R.
• Ebeling, P. R.
• Hartel, G.
• Armstrong, B. K.
• O’Connell, R. L.
• van der Pols, J. C.
• Venn, A. J.
• Webb, P. M.
• Wells, J. K.
• Whiteman, D. C.
• Pickett, H. A.
• Neale, Rachel E.

Titel

Effects of Vitamin D Supplementation on Telomere Length: An Analysis of Data from the Randomised Controlled D-Health Trial

Ist Teil von

• The Journal of nutrition, health & aging, 2023-08, Vol.27 (8), p.609-616

Ort / Verlag

Paris: Springer Paris

Erscheinungsjahr

2023

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Objectives Observational studies have suggested that a higher 25-hydroxyvitamin D concentration may be associated with longer telomere length; however, this has not been investigated in randomised controlled trials. We conducted an ancillary study within a randomised, double-blind, placebo-controlled trial of monthly vitamin D (the D-Health Trial) for the prevention of all-cause mortality, conducted from 2014 to 2020, to assess the effect of vitamin D supplementation on telomere length (measured as the telomere to single copy gene (T/S) ratio). Design, Setting, Participants, and Intervention Participants were Australians aged 60–84 years and we randomly selected 1,519 D-Health participants (vitamin D: n=744; placebo: n=775) for this analysis. We used quantitative polymerase chain reaction to measure the relative telomere length (T/S ratio) at 4 or 5 years after randomisation. We compared the mean T/S ratio between the vitamin D and placebo groups to assess the effect of vitamin D supplementation on relative telomere length, using a linear regression model with adjustment for age, sex, and state which were used to stratify the randomisation. Results The mean T/S ratio was 0.70 for both groups (standard deviation 0.18 and 0.16 for the vitamin D and placebo groups respectively). The adjusted mean difference (vitamin D minus placebo) was −0.001 (95% CI −0.02 to 0.02). There was no effect modification by age, sex, body mass index, or predicted baseline 25-hydroxyvitamin D concentration. Conclusion In conclusion, routinely supplementing older adults, who are largely vitamin D replete, with monthly doses of vitamin D is unlikely to influence telomere length.