Details

Autor(en) / Beteiligte

• Cheng, Hong
• Wang, Jingyu
• Zhang, Yahui
• Tang, Yingle
• Zhu, Lin
• Tao, Yan
• Lu, Wen
• Yang, Haifan
• Zhu, Weiyi
• Tang, Xin
• Qiao, Xinran

Titel

The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease

Ist Teil von

• Journal of neuroimmunology, 2023-10, Vol.383, p.578144-578144, Article 578144

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN). Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD. We developed a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and determined the effects of rLZ-8 on molecular and cellular components of SN and whole brain tissue. The levels of SOD, GSH-Px, p-JAK2 and p-STAT3 in the brain tissue and SN were downregulated, while IL-6, IL-1β, and TNF-α and MDA were upregulated. These effects were significantly reversed upon treatment rLZ-8. In summary, oxidative stress and inflammatory response in PD can be alleviated using rLZ-8. •The immunogenicity of recombinant Ganoderma lucidum immunoregulatory protein (rLZ-8) on mice with Parkinson's disease (PD) was investigated.•Exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) resulted in PD-like phenotype and decreased the level of SOD, GSH-Px, p-JAK2 and p-STAT3 in the brain.•The grid residence, rod turning, and rod climbing times in PD group were significantly prolonged, and the MDA , IL-6, IL-1β, and TNF-α levels in brain were greatly increased.•Treatment with rLZ-8 was found to reverse the parkinsonism-related effects of MPTP in mice.