Details

Autor(en) / Beteiligte

• Micheli, Laura
• Rajamoni, Jagan
• Di Cesare Mannelli, Lorenzo
• Rajagopalan, Parthasarathi
• Ghelardini, Carla
• Rajagopalan, Raghavan

Titel

DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2023-10, Vol.95, p.129472-129472, Article 129472

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] Diabetic neuropathy (DN) is a painful, chronic ailment that affects a large segment of diabetic population worldwide. Current medications such as pregabalin or duloxetine treat only the pain symptom associated with DN, but not the underlying nerve damage. DDD-028 (1) is a small molecule that displays potent pain-relieving activity in streptozotocin (STZ)-induced rodent model of DN. Combined with other studies indicating that DDD-028 suppresses astrogliosis and nerve damage induced by the anti-cancer drug, paclitaxel, the present study suggests that DDD-028 would be useful as a disease modifying therapeutic in the treatment of DN. The 3-dimensional structure of DDD-028 was confirmed by single crystal X-ray crystallography.