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Tumor Differentiation as a Prognostic Marker in Clinically Staged T1bN0 Esophageal Adenocarcinoma
Ist Teil von
Cancer investigation, 2023-09, Vol.41 (8), p.734-738
Erscheinungsjahr
2023
Quelle
Access via Taylor & Francis
Beschreibungen/Notizen
Current guidelines recommend that clinically staged T1N0 esophageal cancers are to be referred to surgery or endoscopic resection. Using the National Cancer Database, we identified 733 individuals with clinically staged T1N0 esophageal carcinoma, who underwent upfront surgery and did not receive any prior treatment. We assessed upstaging, which was defined as ≥ T2 disease or positive lymph nodes. Poorly differentiated adenocarcinomas were associated with upstaging, whereas squamous cell carcinomas were not. Specifically, the percentage of upstaging among individuals with clinically staged T1b and poorly differentiated tumor was 33.8%. Therefore, clinically staged T1bN0 poorly differentiated esophageal adenocarcinomas are at high risk for upstaging following surgery.
Sprache
Englisch
Identifikatoren
ISSN: 0735-7907
eISSN: 1532-4192
DOI: 10.1080/07357907.2023.2255907
Titel-ID: cdi_proquest_miscellaneous_2861305525
Format
–
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