Details

Autor(en) / Beteiligte

• Ma, Yi-Long
• Wu, Zheng-Fang
• Li, Zhi
• Wang, Yue
• Shang, Ya-Fang
• Thakur, Kiran
• Wei, Zhao-Jun

Titel

In vitro digestibility and hepato-protective potential of Lophatherum gracile Brongn. leave extract

Ist Teil von

• Food chemistry, 2024-02, Vol.433, p.137336-137336, Article 137336

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •Digestive performance and hepato-protection of LGE were investigated.•Antioxidant capacity of LGE increased in gastric digestion.•Antioxidant capacity of LGE declined during oral and intestinal digestion.•Phenol compounds in LGE remained highly bio-accessible after in vitro digestion.•LGE pretreatment significantly decreased cellular ROS levels and MDA content. Lophatherum gracile Brongn. (L. gracile) is a traditional herb for both medicine and food use, but its digestibility and hepato-protective activity is unknown. Herein we investigated the digestibility and hepato-protective potential of L. gracile leave extract (LGE) using in vitro digestion and alcohol-induced oxidative damage models. Compared to the undigested group, the content of phenolics/flavonoids and the antioxidant activity in LGE generally decreased by 9.30–19.97% in the oral and small intestine phase after digestion, while that increased by 9.96–10.17% in the gastric phase. The main phenolics/flavonoids showed promising stability during digestion and their bio-accessiblity ranged from 67.64% to 84.47%. By reducing cellular reactive oxidative species and malonaldehyde levels, LGE (0.23–0.45 mg/mL) pretreatment significantly ameliorated alcohol-induced oxidative damage in HepG2 cells (P < 0.05), and their survival rate increased from 59.23% to 67.76%. These findings suggested that L. gracile could be used for the development of hepato-protective foods.