Details

Autor(en) / Beteiligte

• Bartley, Christopher M
• Ngo, Thomas T
• Do, Le Duy
• Zekeridou, Anastasia
• Dandekar, Ravi
• Muñiz-Castrillo, Sergio
• Alvarenga, Bonny D
• Zorn, Kelsey C
• Tubati, Asritha
• Pinto, Anne-Laurie
• Browne, Weston D
• Hullett, Patrick W
• Terrelonge, Mark
• Schubert, Ryan D
• Piquet, Amanda L
• Yang, Binxia
• Montalvo, Mayra
• Kung, Andrew F
• Mann, Sabrina A
• Shah, Maulik P
• Geschwind, Michael D
• Gelfand, Jeffrey M
• DeRisi, Joseph L
• Pittock, Sean J
• Honnorat, Jérôme
• Pleasure, Samuel J
• Wilson, Michael R

Titel

Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins

Ist Teil von

• Annals of neurology, 2023-12, Vol.94 (6), p.1086-1101

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Co-occurring anti-tripartite motif-containing protein 9 and 67 autoantibodies (TRIM9/67-IgG) have been reported in only a very few cases of paraneoplastic cerebellar syndrome. The value of these biomarkers and the most sensitive methods of TRIM9/67-IgG detection are not known. We performed a retrospective, multicenter study to evaluate the cerebrospinal fluid and serum of candidate TRIM9/67-IgG cases by tissue-based immunofluorescence, peptide phage display immunoprecipitation sequencing, overexpression cell-based assay (CBA), and immunoblot. Cases in which TRIM9/67-IgG was detected by at least 2 assays were considered TRIM9/67-IgG positive. Among these cases (n = 13), CBA was the most sensitive (100%) and revealed that all cases had TRIM9 and TRIM67 autoantibodies. Of TRIM9/67-IgG cases with available clinical history, a subacute cerebellar syndrome was the most common presentation (n = 7/10), followed by encephalitis (n = 3/10). Of these 10 patients, 70% had comorbid cancer (7/10), 85% of whom (n = 6/7) had confirmed metastatic disease. All evaluable cancer biopsies expressed TRIM9 protein (n = 5/5), whose expression was elevated in the cancerous regions of the tissue in 4 of 5 cases. TRIM9/67-IgG is a rare but likely high-risk paraneoplastic biomarker for which CBA appears to be the most sensitive diagnostic assay. ANN NEUROL 2023;94:1086-1101.