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Interventions for deficits in recognition of emotions in facial expressions in major depressive disorder: An updated systematic review of clinical trials
Ist Teil von
Neuroscience and biobehavioral reviews, 2023-10, Vol.153, p.105367-105367, Article 105367
Ort / Verlag
Elsevier Ltd
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
The recognition of emotions in facial expressions (REFE) is a core construct of social cognition. In the last decades, studies have showed that REFE is altered in major depressive disorder (MDD), but the evidence is conflicting. Thus, we conducted a systematic review of clinical trials involving therapeutic interventions in MDD and any evaluation of REFE to update (2018–2023) and systematically evaluate the evidence derived from controlled clinical trials on the effects of therapeutic strategies to MDD on the REFE. Eleven studies were included in the final review. Some interventions, including drugs (ketamine, bupropion, psylocibin) and non-pharmacological strategies (psychotherapy) seem to be able to reduce pre-existing REFE biases in MDD patients. However, there was a high heterogeneity in the evaluated studies, in terms of sample, interventions, tasks and results. Further studies and more consistent evaluation tools are highly needed to better understand nuanced deficits and specific actions of different treatment options.
•The recognition of emotions in facial expressions (REFE) is a core construct of social cognition.•REFE is altered in major depressive disorder (MDD).•Antidepressants normalize REFE alterations in MDD.•Psychedelics and psychotherapy reduce REFE biases in MDD.