Details

Autor(en) / Beteiligte

• Zhang, Yuchen
• Ma, Shaoyang
• Nie, Jiaming
• Liu, Zhongbo
• Chen, Faming
• Li, Ang
• Pei, Dandan

Titel

Journey of Mineral Precursors in Bone Mineralization: Evolution and Inspiration for Biomimetic Design

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2024-01, Vol.20 (3), p.e2207951-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Bone mineralization is a ubiquitous process among vertebrates that involves a dynamic physical/chemical interplay between the organic and inorganic components of bone tissues. It is now well documented that carbonated apatite, an inorganic component of bone, is proceeded through transient amorphous mineral precursors that transforms into the crystalline mineral phase. Here, the evolution on mineral precursors from their sources to the terminus in the bone mineralization process is reviewed. How organisms tightly control each step of mineralization to drive the formation, stabilization, and phase transformation of amorphous mineral precursors in the right place, at the right time, and rate are highlighted. The paradigm shifts in biomineralization and biomaterial design strategies are intertwined, which promotes breakthroughs in biomineralization‐inspired material. The design principles and implementation methods of mineral precursor‐based biomaterials in bone graft materials such as implant coatings, bone cements, hydrogels, and nanoparticles are detailed in the present manuscript. The biologically controlled mineralization mechanisms will hold promise for overcoming the barriers to the application of biomineralization‐inspired biomaterials. During bone mineralization, organisms tightly control the formation, stabilization, and phase transition of amorphous mineral precursors through the synergy of ions, biomolecules, and metabolic activities. The in vivo mineralization “on‐off” control mechanisms are also an inspiration for the design of mineral precursor‐based biomaterials, which are used as coatings, cements, hydrogels, and nanoparticles for bone regeneration.