Details

Autor(en) / Beteiligte

• Xiong, Feng
• Wei, Shuo
• Wu, Shuyuan
• Jiang, Wei
• Li, Biyun
• Xuan, Hongyun
• Xue, Ye
• Yuan, Huihua

Titel

Aligned Electroactive Electrospun Fibrous Scaffolds for Peripheral Nerve Regeneration

Ist Teil von

• ACS applied materials & interfaces, 2023-09, Vol.15 (35), p.41385-41402

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Effective repair and functional recovery of large peripheral nerve deficits are urgent clinical needs. A biofunctional electroactive scaffold typically acts as a “bridge” for the repair of large nerve defects. In this study, we constructed a biomimetic piezoelectric and conductive aligned polypyrrole (PPy)/polydopamine (PDA)/poly-l-lactic acid (PLLA) electrospun fibrous scaffold to improve the hydrophilicity and cellular compatibility of PLLA and restore the weakened piezoelectric effect of PDA, which is beneficial in promoting Schwann cell differentiation and dorsal root ganglion neuronal extension and alignment. The aligned PPy/PDA/PLLA fibrous scaffold bridged the sciatic nerve of Sprague–Dawley rats with a 10 mm deficit, prevented autotomy, and promoted nerve regeneration and functional recovery, thereby activating the calcium and AMP-activated protein kinase signaling pathways. Therefore, electroactive fibrous scaffolds exhibit great potential for neural tissue regeneration.