Details

Autor(en) / Beteiligte

• de Oliveira, Renée Sarmento
• Moll-Bernardes, Renata
• de Brito, Adriana Xavier
• Pinheiro, Martha Valéria Tavares
• de Almeida, Sergio Altino
• da Silva Gomes, Natália Lins
• de Oliveira Terzi, Flavia Vernin
• Moreira, Otacílio Cruz
• Xavier, Sergio Salles
• Rosado-de-Castro, Paulo Henrique
• de Sousa, Andréa Silvestre

Titel

Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease

Ist Teil von

• Journal of nuclear cardiology, 2023-12, Vol.30 (6), p.2702-2711

Ort / Verlag

Cham: Elsevier Inc

Erscheinungsjahr

2023

Quelle

SpringerLink

Beschreibungen/Notizen

• Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia might be related to the persistence of parasitemia or inflammation in the myocardium in late-stage CHD. Positron emission tomography/computed tomography (PET/CT) has been used to detect myocardial inflammation in non-ischemic cardiomyopathies, such as sarcoidosis, and might be useful for risk prediction in patients with CHD. Twenty-four outpatients with chronic CHD were enrolled in this prospective cross-sectional study between May 2019 and March 2022. The patients were divided into two groups: those with sustained ventricular tachycardia and/or aborted sudden cardiac death who required implantable cardioverter-defibrillators, and those with the same stages of CHD and no complex ventricular arrhythmia. Patients underwent 18F-fluorodeoxyglucose (18F-FDG) and 68Ga-DOTATOC PET/CT, and blood samples were collected for qualitative parasite assessment by polymerase chain reaction. Although similar proportions of patients with and without complex ventricular arrhythmia showed 18F-FDG and 68Ga-DOTATOC uptake, 68Ga-DOTATOC corrected SUVmax was higher in patients with complex arrhythmia (3.4 vs 1.7; P = .046), suggesting that inflammation could be associated with the presence of malignant arrhythmia in the late stages of CHD. We also detected Trypanosoma cruzi in both groups, with a nonsignificant trend of increased parasitemia in the group with malignant arrhythmia (66.7% vs 33.3%). 18F-FDG and 68Ga-DOTATOC uptake on PET/CT may be useful for the detection of myocardial inflammation in patients with Chagas cardiomyopathy, and 68Ga-DOTATOC uptake may be associated with the presence of malignant arrhythmia, with potential therapeutic implications.