Details

Autor(en) / Beteiligte

• Tanaka, Takehiko
• Umemura, Shigeki
• Miyoshi, Tomohiro
• Nakai, Tokiko
• Noritake, Osamu
• Suzuki, Jun
• Tane, Kenta
• Samejima, Joji
• Aokage, Keiju
• Mimaki, Sachiyo
• Tsuchihara, Katsuya
• Taki, Tetsuro
• Miyazaki, Saori
• Watanabe, Reiko
• Sakashita, Shingo
• Sakamoto, Naoya
• Kojima, Motohiro
• Goto, Koichi
• Ikeda, Norihiko
• Tsuboi, Masahiro
• Ishii, Genichiro

Titel

The prognostic impact of a high number of peritumoral alveolar macrophages in neuroendocrine carcinoma in the lung

Ist Teil von

• Pathology international, 2023-10, Vol.73 (10), p.497-508

Ort / Verlag

Tokyo: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• Abstract Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs located apart from the tumor (distant macrophages; dAMs). In 73 cases of neuroendocrine carcinoma (NEC: small cell lung carcinoma and large cell neuroendocrine carcinoma), the group that contained higher pAMs (≥86/μm 2 ) revealed shorter recurrent‐free survival (RFS) than those with lower pAMs (<86/μm 2 ) ( p  = 0.005). Bivariate analysis showed that the number of pAMs was an independent predictor of a poor RFS. In contrast, in the carcinoid tumor cohort ( n  = 29), there was no statistically significant correlation between the two groups with high and low numbers of pAMs in RFS ( p  = 0.113). Furthermore, we examined the correlation between genomic alterations and the number of pAMs in NEC, but no significant correlation was observed. In conclusion, the number of pAMs is a prognostic factor for NEC in the lung and pAMs may contribute to tumor progression within the peritumoral microenvironment.