Details

Autor(en) / Beteiligte

• Barchitta, M.
• Maugeri, A.
• Favara, G.
• Lio, R. Magnano San
• La Rosa, M.C.
• D'Ancona, F.
• Agodi, A.
• Murgia, P.
• Masia, M.D.
• Mura, I.
• Brusaferro, S.
• Arnoldo, L.
• Di Stefano, C.
• Lucchese, F.
• Lugano, M.
• Tardivo, S.
• Moretti, F.
• Bernasconi, M.O.
• Pappalardo, F.
• Pasquarella, C.
• Sicoli, E.
• Montagna, M.T.
• Caggiano, G.
• De Giglio, O.
• Fenaroli, S.
• Squeri, R.
• Cannavò, G.
• Pulvirenti, A.
• Catalano, S.
• Mattaliano, A.R.
• Castiglione, G.
• Astuto, M.
• La Camera, G.
• Panascia, E.
• Longhitano, A.M.
• Scrofani, G.
• Gallea, M.R.
• Civello, P.
• Milazzo, M.
• Calamusa, G.
• Giarratano, A.
• Di Benedetto, A.
• Rizzo, G.M.G.
• Manta, G.
• Angelone, C.
• Mancuso, R.
• Tetamo, R.
• Mella, L.M.
• Dei, I.
• Pandiani, I.
• Cannistrà, A.
• Piotti, P.
• Girardis, M.
• Barbieri, A.
• Borracino, S.
• Palermo, R.
• Di Stefano, D.
• Colombo, A.
• Romeo, A.
• Minerva, M.
• Fabiani, L.
• Marinangeli, F.
• D’Errico, M.M.
• Donati, A.
• Domizi, R.
• Saglimbene, S.T.
• Bianco, A.
• Vittori, C.
• Orsi, G.B.
• Scibilia, M.
• Calà, O.
• Giacinto, I.
• Amatucci, M.R.
• Principi, T.
• Di Fabio, G.
• Gobbini, V.
• Olori, M.P.
• Antonelli, M.
• Laurenti, P.
• Condorelli, L.
• Ingala, F.
• Russo, S.
• Costa, P.
• Canonico, L.
• Farruggia, P.
• Cristina, M.L.
• Sartini, M.
• Arrigoni, C.
• Galassi, I.
• Vinci, V.M.

Titel

The intertwining of healthcare-associated infections and COVID-19 in Italian intensive care units: an analysis of the SPIN-UTI project from 2006 to 2021

Ist Teil von

• The Journal of hospital infection, 2023-10, Vol.140, p.124-131

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Although healthcare-associated infections (HAIs) pose an extraordinary burden on public health, the impact of coronavirus disease 2019 (COVID-19) is still a matter of debate. To describe trends of HAIs in Italian intensive care units (ICUs) from 2006 to 2021, and to compare characteristics and outcomes of patients with or without COVID-19. We evaluated patients participating in the ‘Italian Nosocomial Infections Surveillance in Intensive Care Units’ (SPIN-UTI) project, who were admitted to ICUs for more than 48 h. Data regarding diagnosis, clinical conditions, therapies, treatments and outcomes of COVID-19 patients were also collected. From a total of 21,523 patients from 2006 to 2021, 3485 (16.2%) presented at least one HAI. We observed an increasing trend for both the incidence of patients with HAI and the incidence density of HAIs (P-trend <0.001). Compared with the pre-pandemic period, the incidence density of HAIs increased by about 15% in 2020–2021, with pneumoniae being the greatest contributors to this increase (P-trend <0.001). Moreover, incidence of HAIs was higher in ICUs dedicated to COVID-19 patients (P<0.001), who showed a greater risk of HAIs and death than patients without COVID-19 (P-values <0.001). Accordingly, the mortality in ICUs increased over the years and doubled during the pandemic (P-trend <0.001). Notably, co-infected patients had higher mortality (75.2%) than those with COVID-19 (66.2%) or HAI (39.9%) alone, and those without any infection (23.2%). Our analysis provides useful insight into whether and how the COVID-19 pandemic influenced HAI incidence and death in Italian ICUs, highlighting the need for evaluation of the long-term effects of the pandemic.