Details

Autor(en) / Beteiligte

• Rábade-Castedo, Carlos
• de Granda-Orive, José Ignacio
• Riesco-Miranda, Juan Antonio
• De Higes-Martínez, Eva
• Ramos-Pinedo, Ángela
• Cabrera-César, Eva
• Signes-Costa Miñana, Jaime
• García Rueda, Marcos
• Pastor-Esplá, Esther
• Jiménez-Ruiz, Carlos A.

Titel

Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023

Ist Teil von

• Archivos de bronconeumología (English ed.), 2023-10, Vol.59 (10), p.651-661

Ort / Verlag

Spain: Elsevier España, S.L.U

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• There are multiple systematic reviews and meta-analyses on the efficacy and safety of pharmacological treatments against nicotine dependence. However, there are few guidelines to answer frequent questions asked by a clinician treating a smoker. Therefore, the aim of this paper is to facilitate the treatment of tobacco addiction. 12 PICO questions are formulated from a GLOBAL PICO question: “Efficacy and safety of pharmacological treatment of tobacco dependence”. A systematic review was carried out to answer each of the questions and recommendations were made. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system was used to grade the certainty of the estimated effects and the strength of the recommendations. Varenicline, nicotine replacement therapy (NRT), bupropion and cytisine are more effective than placebo. Varenicline and combined nicotine therapy are superior to the other therapies. In smokers with high dependence, a combination of drugs is recommended, being more effective those associations containing varenicline. Other optimization strategies with lower efficacy consist of increasing the doses, the duration, or retreat with varenicline. In specific populations varenicline or NRT is recommended. In hospitalized, the treatment of choice is NRT. In pregnancy it is indicated to prioritize behavioral treatment. The financing of smoking cessation treatments increases the number of smokers who quit smoking. There is no scientific evidence of the efficacy of pharmacological treatment of smoking cessation in adolescents. The answers to the 12 questions allow us to extract recommendations and algorithms for the pharmacological treatment of tobacco dependence.