Details

Autor(en) / Beteiligte

• Canonica, Giorgio Walter
• Blasi, Francesco
• Carpagnano, Giovanna Elisiana
• Guida, Giuseppe
• Heffler, Enrico
• Paggiaro, Pierluigi
• Allegrini, Chiara
• Antonelli, Andrea
• Aruanno, Arianna
• Bacci, Elena
• Bagnasco, Diego
• Beghè, Bianca
• Bonavia, Marco
• Bonini, Matteo
• Brussino, Luisa
• Caiaffa, Maria Filomena
• Calabrese, Cecilia
• Camiciottoli, Gianna
• Caminati, Marco
• Caruso, Cristiano
• Cavallini, Mirta
• Chieco Bianchi, Fulvia
• Conte, Maria Elisabetta
• Corsico, Angelo Guido
• Cosmi, Lorenzo
• Costantino, Mariateresa
• Costanzo, Giulia
• Crivellaro, Mariaangiola
• D'Alò, Simona
• D'Amato, Mariella
• Detoraki, Aikaterini
• Di Proietto, Maria Carmela
• Facciolongo, Nicola Cosimo
• Ferri, Sebastian
• Fierro, Vincenzo
• Foschino, Maria Pia
• Latorre, Manuela
• Lombardi, Carlo
• Macchia, Luigi
• Milanese, Manlio
• Montagni, Marcello
• Parazzini, Elena Maria
• Parente, Roberta
• Passalacqua, Giovanni
• Patella, Vincenzo
• Pelaia, Girolamo
• Pini, Laura
• Puggioni, Francesca
• Ricciardi, Luisa
• Ridolo, Erminia
• Rolo, Joyce
• Scichilone, Nicola
• Scioscia, Giulia
• Senna, Gianenrico
• Solidoro, Paolo
• Varricchi, Gilda
• Vianello, Andrea
• Yacoub, Mona Rita
• Yang, Baoran

Titel

Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus

Ist Teil von

• The journal of allergy and clinical immunology in practice (Cambridge, MA), 2023-12, Vol.11 (12), p.3629-3637

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Severe asthma affects about 10% of the population with asthma and is characterized by low lung function and a high count of blood leukocytes, mainly eosinophils. Various definitions are used in clinical practice and in the literature to identify asthma remission: clinical remission, inflammatory remission, and complete remission. This work highlights a consensus for asthma remission using a Delphi method. In the context of the Severe Asthma Network Italy, which accounts for 57 severe asthma centers and more than 2,200 patients, a board of six experts drafted a list of candidate statements in a questionnaire, which has been revised to minimize redundancies and ensure clear and consistent wording for the first round (R1) of the analysis. Thirty-two statements were included in the R1 questionnaire and then submitted to a panel of 80 experts, which used a 5-point Likert scale to measure agreement regarding each statement. Then, an interim analysis of R1 data was performed, and items were discussed and considered to produce a consistent questionnaire for round 2 (R2) of the analysis. Then, the board set the R2 questionnaire, which included only important topics. Panelists were asked to vote on the statements in the R2 questionnaire afterward. During R2, the criteria of complete clinical remission (the absence of the need for oral corticosteroids, symptoms, exacerbations or attacks, and pulmonary function stability) and those of partial clinical remission (the absence of the need for oral corticosteroids, and two of three criteria: the absence of symptoms, exacerbations or attacks, and pulmonary stability) were confirmed. This Severe Asthma Network Italy Delphi analysis defined a valuable and independent tool that is easy to use, to test the efficacy of different treatments in patients with severe asthma enrolled into the SANI registry.