Details

Autor(en) / Beteiligte

• Carrasco Colom, Jaime
• Manzanares, Ángela
• Álvaro Gómez, Alicia
• Serrano Escribano, Isabel
• Esquivel, Estrella
• Pérez-Rivilla, Alfredo
• Moral-Pumarega, Maria Teresa
• Aguirre Pascual, Elisa
• De Vergas, Joaquín
• Reda del Barrio, Sara
• Moraleda, Cinta
• Epalza, Cristina
• Fernández-Cooke, Elisa
• Prieto, Luis
• Villaverde, Serena
• Zamora, Berta
• Herraiz, Ignacio
• Galindo, Alberto
• Folgueira, María Dolores
• Delgado, Rafael
• Blázquez-Gamero, Daniel

Titel

Clinical outcomes and antibody transfer in a cohort of infants with in utero or perinatal exposure to SARS-CoV-2 (Coronascope Study)

Ist Teil von

• European journal of pediatrics, 2023-10, Vol.182 (10), p.4647-4654

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We aimed to describe the outcomes, focusing on the hearing and neurological development, of infants born to mothers with COVID-19 during pregnancy and to evaluate the persistence of maternal antibodies in the first months of life. An observational, prospective study at a tertiary hospital in Madrid (Spain) on infants born to mothers with COVID-19 during pregnancy between March and September 2020 was conducted. A follow-up visit at 1–3 months of age with a physical and neurological examination, cranial ultrasound (cUS), SARS-CoV-2 RT-PCR on nasopharyngeal swab, and SARS-CoV-2 serology were performed. Hearing was evaluated at birth through the automated auditory brainstem response and at six months of age through the auditory steady-state response. A neurodevelopmental examination using the Bayley-III scale was performed at 12 months of age. Of 95 infants studied, neurological examination was normal in all of them at the follow-up visit, as was the cUS in 81/85 (95%) infants, with only mild abnormalities in four of them. Serology was positive in 47/95 (50%) infants, which was not associated with symptoms or severity of maternal infection. No hearing loss was detected, and neurodevelopment was normal in 96% of the infants (median Z score: 0). Conclusion : In this cohort, the majority of infants born to mothers with COVID-19 during pregnancy were healthy infants with a normal cUS, no hearing loss, and normal neurodevelopment in the first year of life. Only half of the infants had a positive serological result during the follow-up. What is Known: • Hearing loss and neurodevelopmental delay in infants born to mothers with COVID-19 during pregnancy has been suggested, although data is inconsistent. Maternal antibody transfer seems to be high, with a rapid decrease during the first weeks of life. What is New: • Most infants born to mothers with COVID-19 during pregnancy had normal hearing screening, cranial ultrasound, and neurodevelopmental status at 12 months of life. Antibodies against SARS-CoV-2 were only detected in 50% of the infants at two months of life.