Details

Autor(en) / Beteiligte

• Hensel, Lukas
• Seger, Aline
• Farrher, Ezequiel
• Bonkhoff, Anna K.
• Shah, N. Jon
• Fink, Gereon R.
• Grefkes, Christian
• Sommerauer, Michael
• Doppler, Christopher E.J.

Titel

Fronto-striatal dynamic connectivity is linked to dopaminergic motor response in Parkinson's disease

Ist Teil von

• Parkinsonism & related disorders, 2023-09, Vol.114, p.105777-105777, Article 105777

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Differences in dopaminergic motor response in Parkinson's disease (PD) patients can be related to PD subtypes, and previous fMRI studies associated dopaminergic motor response with corticostriatal functional connectivity. While traditional fMRI analyses have assessed the mean connectivity between regions of interest, an important aspect driving dopaminergic response might lie in the temporal dynamics in corticostriatal connections. This study aims to determine if altered resting-state dynamic functional network connectivity (DFC) is associated with dopaminergic motor response. To test this, static and DFC were assessed in 32 PD patients and 18 healthy controls (HC). Patients were grouped as low and high responders using a median split of their dopaminergic motor response. Patients featuring a high dopaminergic motor response were observed to spend more time in a regionally integrated state compared to HC. Furthermore, DFC between the anterior midcingulate cortex/dorsal anterior cingulate cortex (aMCC/dACC) and putamen was lower in low responders during a more segregated state and correlated with dopaminergic motor response. The findings of this study revealed that temporal dynamics of fronto-striatal connectivity are associated with clinically relevant information, which may be considered when assessing functional connectivity between regions involved in motor initiation. •Patients with Parkinson's disease maintain distinct transient connectivity states depending on their dopaminergic responses.•Patients with a high dopaminergic response showed longer dwell times in a state of higher integration of brain regions.•Low dopaminergic response was linked to reduced dynamic functional connectivity between the aMCC/aACC and the putamen.•This link was not found in static functional connectivity, i.e. the mean connectivity between identical regions over time.