Details

Autor(en) / Beteiligte

• Siddiqui, Saima Haleem
• Thakral, Beenu
• Aakash, FNU
• Ok, Chi Young
• Tang, Zhenya
• Medeiros, L. Jeffrey

Titel

From the archives of MD Anderson Cancer Center: Sporadic Burkitt lymphoma with a complex karyotype and SOX11 expression

Ist Teil von

• Annals of diagnostic pathology, 2023-10, Vol.66, p.152182-152182, Article 152182

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Burkitt lymphoma (BL) is a mature B-cell neoplasm arising from germinal center B-cells. There are three epidemiological variants of which the sporadic variant is most prevalent in developed countries representing 1–2 % of all lymphomas in adults. Patients usually present with bulky abdominal masses and ~ 30 % have bone marrow involvement. BL is characterized by a germinal center B-cell immunophenotype and usually has a simple karyotype. Here we report an unusual case of sporadic BL in a 44-year-old man and we use this case to review sporadic BL in adults. The patient presented with a cecal mass and bone marrow involvement. Biopsy of the cecal mass and bone marrow evaluation showed infiltration by intermediate-size lymphoma cells positive for monotypic kappa, CD10, CD19, CD20, CD22, CD38 bright, CD43, CD45, Bcl6 and ROR1, and negative for CD11c, CD23, CD30, CD44, CD200 and Bcl2. As expected, the lymphoma cells were strongly positive for MYC and Ki-67 showed a proliferation rate of nearly 100 %, but the cells were also positive for SOX11 and cytoplasmic LEF1. Conventional chromosomal analysis revealed t(8;14) as part of a complex karyotype. Based on our literature review, and is shown in this case, sporadic BL in adults shows some differences with the classic description of BL in children. We also discuss the differential diagnosis of BL. •Sporadic Burkitt lymphoma often presents with extranodal involvement and bulky abdominal disease.•These neoplasms are positive for pan B-cell and germinal center B-cell markers and negative for Bcl2.•MYC/8q24 translocation and overexpression of MYC are characteristic features.•Aberrant expression of SOX11 and a complex karyotype is not uncommon.