Details

Autor(en) / Beteiligte

• Castro‐Santos, Patricia
• Díaz‐Peña, Roberto
• Abellan, Javier
• Alcoba‐Florez, Julia
• Batres, Sergio Alcolea
• Algarin‐Lara, Holmes Rafael
• Álvarez‐Navia, Felipe
• Araujo, Nathalia K.
• Araujo, Izabel M. T.
• Arnaiz, Ana
• Fernández, Francisco Arnalich
• Baldion, Ana María
• Martín, Belén Ballina
• Barreda‐Sánchez, María
• Bezerra, Joao F.
• Bezerra, Marcos A. C.
• Bustos, Matilde
• Calbo, Esther
• Camacho, Shirley
• Carpintero, Maria Sanchez
• Candalija, Aranzazu Castellano
• Cid‐Lopez, Marco A.
• Corton, Marta
• Cruz, Raquel
• Cruz, Marina S.
• Silva, Gabriela V.
• De Martino‐Rodríguez, Alba
• Enciso‐Olivera, César O.
• Escudero, Gabriela
• Fernandes, Marianne R.
• Fernández‐Rodríguez, Amanda
• Martínez, Yolanda Fernández
• Capitán, Carmen Fernéndez
• Fumadó, Victoria
• García, Mercedes
• Garcia‐García, Josefina
• García‐Montero, Andrés C.
• Gil‐Fournier, Belén
• Gómez‐Duque, Mario
• González‐Neira, Anna
• Quirós, Fernan Gonzalez Bernaldo
• Górgolas, Miguel
• Guillen‐Navarro, Encarna
• Gutiérrez‐Bautista, Juan F.
• Gutierrez‐Castañeda, Luz D.
• Heili‐Frades, Sarah
• Herrera, María
• Herrero‐Gonzalez, Antonio
• Jacomo, Rafael H.
• Jiménez‐Alfaro, Ignacio
• Lattig, María Claudia
• Lozano‐Espinosa, María
• Aguilar, Pablo Mariscal
• Martín, María Dolores
• Martín, Vicente
• Martín‐Oterino, José‐Ángel
• Martin‐Pedraza, Laura
• Martínez, Silvia
• Martínez‐González, Óscar
• Marzal, Laura
• Medeiros, Kelliane A.
• Morelos‐Arnedo, Xenia
• Nevado, Julian
• Nieto‐Gañán, Israel
• Ocejo‐Vinyals, J. Gonzalo
• Ortiz‐Flores, Fernando
• Ortiz‐Lopez, Rocio
• Conejo, Irene Padilla
• Paz‐Artal, Estela
• Peces‐Barba, Germán
• Perales, Celia
• Perez, Patricia
• Pérez‐Matute, Patricia
• Pérez‐Serra, Alexandra
• León, Soraya Ramiro
• Romero‐Coronado, Andrea
• Rosales‐Castillo, Antonio
• Ruiz‐Cubillan, Juan J.
• Ryan, Pablo
• Sánchez‐Pablo, Clara
• Sánchez‐Pernaute, Olga
• Schlüter, Agatha
• Segovia, Sonia
• Puras, Fernando Sevil
• Porras, Marta Sevilla
• Silva, Nayara S.
• Silva, Fabiola T. C.
• Solé‐Violán, Jordi
• Suarez‐Zamora, David A.
• Castaño, Jair Antonio Tenorio
• Torres‐Tobar, Lilian
• Urioste, Miguel
• Vasconcelos, Romero H. T.
• Vélez‐Santamaría, Valentina
• Villalobos, Lavinia
• Villoslada‐Blanco, Pablo
• Zapatero‐Gaviria, Antonio
• Heredia, Miguel López
• Sande, Esther
• Riancho, José A.

Titel

HLA‐A11:01 and HLA‐C04:01 are associated with severe COVID‐19

Ist Teil von

• HLA, 2023-12, Vol.102 (6), p.731-739

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2023

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• We analyzed the association between HLA polymorphisms and susceptibility to SARS‐CoV‐2 infection and disease severity. Genotyping data from a total of 9373 COVID‐19‐positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID‐19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA‐B*14:02 and HLA‐C*08:02 with a lower risk to COVID‐19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75–0.95], p = 0.024, OR = 0.86, 95% CI = [0.78–0.95], respectively). We also found the alleles HLA‐A*11:01 and HLA‐C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04–1.31], p = 0.045, OR = 1.14, 95% CI = [1.05–1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID‐19.