Details

Autor(en) / Beteiligte

• Ivanov, Mark V.
• Garibova, Leyla A.
• Postoenko, Valeriy I.
• Levitsky, Lev I.
• Gorshkov, Mikhail V.

Titel

On the excessive use of coefficient of variation as a metric of quantitation quality in proteomics

Ist Teil von

• Proteomics (Weinheim), 2024-01, Vol.24 (1-2), p.e2300090-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The coefficient of variation (CV) is often used in proteomics as a proxy to characterize the performance of a quantitation method and/or the related software. In this note, we question the excessive reliance on this metric in quantitative proteomics that may result in erroneous conclusions. We support this note using a ground‐truth Human‐Yeast‐E. coli dataset demonstrating in a number of cases that erroneous data processing methods may lead to a low CV which has nothing to do with these methods’ performances in quantitation.