Details

Autor(en) / Beteiligte

• Patil, Vaibhav
• Bohara, Raghvendra
• Krishna Kanala, Vijaya
• McMahon, Siobhan
• Pandit, Abhay

Titel

Models and approaches to comprehend and address glial inflammation following spinal cord injury

Ist Teil von

• Drug discovery today, 2023-10, Vol.28 (10), p.103722-103722, Article 103722

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •An overview of anti-inflammatory strategies for treating activated glial cells.•Limitations of current in vitro and ex vivo models.•A clinical perspective on drug screening for treating spinal cord injury (SCI).•Recent high-throughput screening platforms.•Anti-inflammatory therapeutic strategies for SCI. Spinal cord injury (SCI) culminates in chronic inflammation and glial scar formation driven by the activation of microglia and astrocytes. Current anti-inflammatory strategies to treat glial activation associated with SCI have several limitations. Existing in vitro and ex vivo models studying molecular mechanisms associated with inflammation focus only on the acute phase. However, the progression of glial cell-derived inflammation over the acute-to-chronic phases has not been assessed. Understanding this progression will help establish a framework for evaluating therapeutic strategies. Additionally, new models could be useful as high-throughput screening (HTS) platforms. This review aims to highlight currently available models and future methods that could facilitate screening of novel therapeutics for SCI.