Details

Autor(en) / Beteiligte

• Aripov, V. S.
• Volkova, N. V.
• Taranin, A. V.
• Mechetina, L. V.
• Chikaev, N. A.
• Nayakshin, A. M.
• Nesmeyanova, V. S.
• Isaeva, A. A.
• Merkul’eva, Yu. A.
• Shanshin, D. V.
• Belenkaya, S. V.
• Ilyichev, A. A.
• Shcherbakov, D. N.

Titel

The Search for Single-Domain Antibodies Interacting with the Receptor-Binding Domain of SARS-CoV-2 Surface Protein

Ist Teil von

• Bulletin of experimental biology and medicine, 2023-06, Vol.175 (2), p.225-228

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2023

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• We performed a search for nanoantibodies that specifically interact with the receptor-binding domain (RBD) of the SARS-CoV-2 surface protein. The specificity of single-domain antibodies from the blood sera of a llama immunized with RBD of SARS-CoV-2 surface protein S (variant B.1.1.7 (Alpha)) was analyzed by ELISA. Recombinant trimers of the SARS-CoV-2 spike protein were used as antigens. In this work, a set of single-domain antibodies was obtained that specifically bind to the RBD of the SARS-CoV-2 virus.