Details

Autor(en) / Beteiligte

• Huang, Zhongjia
• Guo, Lianxian
• Chen, Xu
• Sun, Jiadi
• Ye, Yongli
• Sheng, Lina
• Zhang, Yinzhi
• Zhou, Jianzhong
• Ji, Jian
• Sun, Xiulan

Titel

Long-term chronic food-derived arsenic exposure induce the urinary system metabolic dysfunction in mice

Ist Teil von

• The Science of the total environment, 2023-11, Vol.898, p.165499-165499, Article 165499

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The consumption of rice contaminated with arsenic on a long-term basis has emerged as a pressing public health issue of global significance. Arsenic-induced urinary injury, particularly kidney damage, has received widespread attention. In this study, mice model under long-term arsenic exposure was established, mouse were exposed to rice arsenic (30 mg/kg) for 14 months. Changes of related metabolites were observed based on kidney metabolomics and lipidomics, and major biomarkers were screened by urine metabolomics. The results showed that phosphatidylethanolamine (PE) was significantly increased and phosphatidycholine (PC) and phosphatidylglycerol (PG) were significantly reduced after arsenic exposure, leading to related downstream lipid metabolism disorders. The metabolic pathways for amino acid and energy were observed to be impacted. In addition, metabolic disorders due to arsenic exposure may be associated with inherited neurometabolic disorders, such as D-2-hydroxyglutaric aciduria (D-2-HGA), and pyruvate carboxylase deficiency (PCD), which is predicted based on significant difference biomarkers (2-oxoglutarate, malic acid, and succinic acid) screened for urine. This study elucidates the mechanism of toxicity in the urinary system induced by arsenic exposure at nearly half life cycle, which furnishes crucial scientific evidence pertaining to the toxicity and risk evaluation associated with chronic exposure to the arsenic. [Display omitted] •Long-term arsenic exposure leads to the PE lipids was significantly increased and the PC and PG decreased.•Arsenic-induced kidney metabolic disturbances are primarily through perturbations of amino acid metabolism and energy metabolism.•Urine metabolic markers (eg. 2−oxoglutarate, malic acid, and succinic acid) of long-term chronic arsenic exposure were identified.