Details

Autor(en) / Beteiligte

• Arbour, Christine A
• Fay, Ellen M
• McGouran, Joanna F
• Imperiali, Barbara

Titel

Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A

Ist Teil von

• Organic & biomolecular chemistry, 2023-07, Vol.21 (28), p.5873-5879

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nucleoside analogs show useful bioactive properties. A versatile solid-phase synthesis that readily enables the diversification of thymine-containing nucleoside analogs is presented. The utility of the approach is demonstrated with the preparation of a library of compounds for analysis with SNM1A, a DNA damage repair enzyme that contributes to cytotoxicity. This exploration provided the most promising nucleoside-derived inhibitor of SNM1A to date with an IC 50 of 12.3 μM. Generating a library of thymine-containing nucleoside inhibitors of a DNA repair nuclease enzyme through a divergent solid-phase synthetic approach.