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Pseudobudding: ruptured glands do not represent true tumor buds
The Journal of pathology, 2023-09, Vol.261 (1), p.19-27
Haddad, Tariq Sami
Dobbelsteen, Luuk
Öztürk, Sonay K
Geene, Robin
Nijman, Isaäc J
Verrijp, Kiek
Jamieson, Nigel B
Wood, Colin
Vliet, Shannon
Reuvers, Luuk
Achouiti, Soumia
Rutgers, Natasja
Brouwer, Nelleke
Simmer, Femke
Zlobec, Inti
Lugli, Alessandro
Nagtegaal, Iris D
2023
Details
Autor(en) / Beteiligte
Haddad, Tariq Sami
Dobbelsteen, Luuk
Öztürk, Sonay K
Geene, Robin
Nijman, Isaäc J
Verrijp, Kiek
Jamieson, Nigel B
Wood, Colin
Vliet, Shannon
Reuvers, Luuk
Achouiti, Soumia
Rutgers, Natasja
Brouwer, Nelleke
Simmer, Femke
Zlobec, Inti
Lugli, Alessandro
Nagtegaal, Iris D
Titel
Pseudobudding: ruptured glands do not represent true tumor buds
Ist Teil von
The Journal of pathology, 2023-09, Vol.261 (1), p.19-27
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Tumor budding (TB) is a strong biomarker of poor prognosis in colorectal cancer and other solid cancers. TB is defined as isolated single cancer cells or clusters of up to four cancer cells at the invasive tumor front. In areas with a large inflammatory response at the invasive front, single cells and cell clusters surrounding fragmented glands are observed appearing like TB. Occurrence of these small groups is referred to as pseudobudding (PsB), which arises due to external influences such as inflammation and glandular disruption. Using a combination of orthogonal approaches, we show that there are clear biological differences between TB and PsB. TB is representative of active invasion by presenting features of epithelial‐mesenchymal transition and exhibiting increased deposition of extracellular matrix within the surrounding tumor microenvironment (TME), whereas PsB represents a reactive response to heavy inflammation where increased levels of granulocytes within the surrounding TME are observed. Our study provides evidence that areas with a strong inflammatory reaction should be avoided in the routine diagnostic assessment of TB. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.6146
Titel-ID: cdi_proquest_miscellaneous_2833649133
Format
–
Schlagworte
Cancer
,
Colorectal cancer
,
Colorectal carcinoma
,
Epithelial-Mesenchymal Transition
,
Extracellular matrix
,
Humans
,
immunohistochemistry
,
Inflammation
,
Invasiveness
,
Leukocytes (granulocytic)
,
multiplex immunofluorescence
,
Neoplasms
,
pseudobudding
,
spatial transcriptomics
,
transmission electron microscopy
,
Tuberculosis
,
tumor budding
,
Tumor Microenvironment
,
Tumors
,
United Kingdom
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