Details

Autor(en) / Beteiligte

• Nakagawasai, Osamu
• Yamada, Kotaro
• Takahashi, Kohei
• Oshima, Yuko
• Hayasaka, Sena
• Shoji, Kazuaki
• Nemoto, Wataru
• Tan-No, Koichi

Titel

Effect of Globin Digests on Physical Fatigue in Mice

Ist Teil von

• Biological and Pharmaceutical Bulletin, 2023/07/01, Vol.46(7), pp.1027-1030

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Globin digest (GD) inhibits dietary hypertriglyceridemia; however, its effects on physical fatigue remain unknown. Therefore, this study aimed to investigate the potential anti-fatigue effects of GD. Repeated administration of GD and valine (Val)-Val-tyrosine (Tyr)-proline (Pro), a component of GD, for five days prevented the forced walking-induced decrease in locomotion. Furthermore, GD treatment reversed the forced walking-induced increase in blood lactate levels in mice and increased phosphorylated AMP-activated protein kinase (p-AMPK) in the soleus muscle, suggesting that the anti-fatigue effect of GD involves AMPK activation in the soleus muscle through reduced blood lactate.