Details

Autor(en) / Beteiligte

• Yao, Shuncheng
• Wang, Shaobo
• Zheng, Minjia
• Wang, Zhuo
• Liu, Zhirong
• Wang, Zhong Lin
• Li, Linlin

Titel

Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy Through Disrupting Microtubule and Actins Dynamics

Ist Teil von

• Advanced materials (Weinheim), 2023-10, Vol.35 (40), p.e2303962-e2303962

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Electric field-based stimulation is emerging as a new cancer therapeutic modality through interfering with cell mitosis. To address its limitations of complicated wire connections, bulky devices, and coarse spatial resolution, we propose an improved and alternative method for wirelessly delivering electrical stimulation into tumor tissues through designing an implantable, biodegradable and wirelessly controlled therapeutic triboelectric nanogenerator (ET-TENG). With the excitation of ultrasound (US) to the ET-TENG, the implanted ET-TENG can generate an alternating current voltage and concurrently release the loaded anti-mitotic drugs into tumor tissues, which synergistically disrupts the assembly of microtubules and filament actins, induces cell cycle arrest, and finally enhances cell death. With the assistance of US, the device can be completely degraded after the therapy, getting free of a secondary surgical extraction. The device can not only work around those unresectable tumors, but also provides a new application of wireless electric field in cancer therapy. This article is protected by copyright. All rights reserved.