Details

Autor(en) / Beteiligte

• Park, Byeongho
• Bang, Seokyoung
• Hwang, Kyeong Seob
• Cha, Yeon Kyung
• Kwak, Jisung
• Tran, Na Ly
• Kim, Hyo‐Suk
• Park, Subeen
• Oh, Seung Ja
• Im, Maesoon
• Chung, Sooyoung
• Kim, Jongbaeg
• Park, Tai Hyun
• Song, Hyun Seok
• Kim, Hong Nam
• Kim, Jae Hun

Titel

Eye‐Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins

Ist Teil von

• Advanced materials (Weinheim), 2023-09, Vol.35 (35), p.e2302996-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley Online Library

Beschreibungen/Notizen

• An in vitro model, composed of the short‐wavelength human opsins and rhodopsins, is created. Two types of photosensitive neural spheroids are transfected for selective reaction under bluish‐purple and green lights. These are employed to two devices with intact neuron and neural‐spheroid to study the interaction. By photostimulation, the photosensitive spheroid initiated photoactivation, and the signal generated from its body is transmitted to adjacent neural networks. Specifically, the signal traveled through the axon bundle in narrow gap from photosensitive spheroid to intact spheroid as an eye‐to‐brain model including optic nerve. The whole process with photosensitive spheroid is monitored by calcium ion detecting fluorescence images. The results of this study can be applied to examine vision restoration and novel photosensitive biological systems with spectral sensitivity. The eye‐to‐brain mimicking model is designed with photosensitive neural spheroid and neural network. In the photosensitive neural spheroid, human opins such as rhodopsin and short‐wavelength opsin are reacted by the specific wavelength of light with selective sensitivity. Photonic reaction result in the neural response, of which signal spread to other neurons through axons.