Details

Autor(en) / Beteiligte

• Endo, Daisuke
• Kinoshita, Takeshi
• Lee, Jiyoung
• Machida, Yoichiro
• Nishida, Kosuke
• Sato, Yuichiro
• Yamamoto, Taira
• Tabata, Minoru

Titel

Left Atrial Appendage Closure During Coronary Bypass Surgery in Patients on Hemodialysis

Ist Teil von

• Circulation Journal, 2023/06/23, Vol.87(7), pp.982-989

Ort / Verlag

Japan: The Japanese Circulation Society

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Patients with end-stage renal disease on hemodialysis (ESRD-HD) have a lifelong risk of atrial fibrillation-related stroke. We compared clinical outcomes in ESRD-HD patients undergoing coronary artery bypass grafting (CABG) with and without concomitant left atrial appendage (LAA) closure.Methods and Results: Of 2,783 consecutive patients undergoing isolated CABG between 2002 and 2020, 242 patients had ESRD-HD with sinus rhythm. The primary outcome was a composite of death and stroke. An inverse probability (IP)-weighted cohort was created based on the propensity score. The 2 IP-weighted groups had well-balanced baseline and surgical backgrounds, with an equivalent follow-up. Five-year stroke-free survival was significantly higher in patients with LAA closure (log-rank test, P=0.035). The adjusted hazard ratio of LAA closure for death and stroke was 0.43 (95% confidence interval [CI] 0.20–0.92; P=0.023). Competing risk analysis showed that LAA closure was significantly associated with a risk reduction of stroke (subhazard ratio 0.26; 95% CI 0.08–0.96; P=0.028). No significant difference was observed in adjusted risk ratios for reoperation for bleeding, new atrial fibrillation, 30-day mortality, and readmission for heart failure.Conclusions: Concomitant LAA closure during CABG can reduce the risk of death and stroke in ESRD-HD patients with normal sinus rhythm.