Details

Autor(en) / Beteiligte

• Qi, Suo-Suo
• Luo, Xin
• Sun, Xiao-Ping
• Zhai, Jing-Jing
• Chu, Ming-Ming
• Chen, Jin
• Wang, Yi-Feng
• Xu, Dan-Qian

Titel

Metal-free and enantioselective synthesis of 1,4-benzoxazepines from para -quinone methide derivatives and α-bromohydroxamates

Ist Teil von

• Chemical communications (Cambridge, England), 2023-07, Vol.59 (57), p.8822-8825

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A sequential asymmetric conjugate addition/cyclisation of α-bromohydroxamates with -quinone methide derivatives has been developed, which provides enantioenriched 1,4-benzoxazepines in generally high yields (up to 95%) and good enantioselectivities (up to 97 : 3 er). This protocol not only offers a novel and straightforward strategy for constructing chiral 1,4-benzoxazepines, but also demonstrates the potential of α-bromohydroxamates as three-atom synthons in asymmetric cyclisation reactions.