Details

Autor(en) / Beteiligte

• Xiao, Wen
• Wang, Su-Jing
• Yu, Ming-Zhu
• Zhang, Xue-Jie
• Xiang, Zheng

Titel

Chemoenzymatic synthesis of (+)-isoagatholactone, (+)-spongian-16-one, and 3-deoxychavalone A via biocatalytic polyene cyclization

Ist Teil von

• Organic & biomolecular chemistry, 2023-07, Vol.21 (27), p.5527-5531

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The stereoselective cyclization of geranylgeraniol catalysed by squalene-hopene cyclase (SHC) was investigated. By use of this transformation, spongiane diterpenoids (+)-isoagatholactone and (+)-spongian-16-one, and meroterpenoid 3-deoxychavalone A were synthesized in a concise and redox-economic manner. This work showcases the application of SHC-catalysed cyclization as a key step in terpenoid synthesis.