Details

Autor(en) / Beteiligte

• Lee, Jakleen J.
• Piras, Enrica
• Tamburini, Sabrina
• Bu, Kevin
• Wallach, David S.
• Remsen, Brooke
• Cantor, Adam
• Kong, Jennifer
• Goetz, Deborah
• Hoffman, Kevin W.
• Bonner, Mharisi
• Joe, Peter
• Mueller, Bridget R.
• Robinson-Papp, Jessica
• Lotan, Eyal
• Gonen, Oded
• Malaspina, Dolores
• Clemente, Jose C.

Titel

Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study

Ist Teil von

• Psychiatry research, 2023-08, Vol.326, p.115279-115279, Article 115279

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• •The oral microbiome is significantly altered in psychiatric disease, with an enrichment in pathogenic taxa like Veillonella and Prevotella, and can accurately classify psychiatric phenotype.•The gut microbiome of psychiatric cases exhibits significantly greater heterogeneity of microbial diversity than in healthy controls.•Gut and oral microbiota differentially associate with the severity of positive and general PANSS scores.•Psychiatric disease is characterized by a dysregulation of the relation between the microbiome and peripheral and hippocampal inflammation.•Associations between microbiota and inflammatory markers in the periphery and hippocampus identify potential gut-brain axis mechanisms. Although increasing evidence links microbial dysbiosis with the risk for psychiatric symptoms through the microbiome-gut-brain axis (MGBA), the specific mechanisms remain poorly characterized. In a diagnostically heterogeneous group of treated psychiatric cases and nonpsychiatric controls, we characterized the gut and oral microbiome, plasma cytokines, and hippocampal inflammatory processes via proton magnetic resonance spectroscopic imaging (1H-MRSI). Using a transdiagnostic approach, these data were examined in association with schizophrenia-related symptoms measured by the Positive and Negative Syndrome Scale (PANSS). Psychiatric cases had significantly greater heterogeneity of gut alpha diversity and an enrichment of pathogenic taxa, like Veillonella and Prevotella, in the oral microbiome, which was an accurate classifier of phenotype. Cases exhibited significantly greater positive, negative, and general PANSS scores that uniquely correlated with bacterial taxa. Strong, positive correlations of bacterial taxa were also found with cytokines and hippocampal gliosis, dysmyelination, and excitatory neurotransmission. This pilot study supports the hypothesis that the MGBA influences psychiatric symptomatology in a transdiagnostic manner. The relative importance of the oral microbiome in peripheral and hippocampal inflammatory pathways was highlighted, suggesting opportunities for probiotics and oral health to diagnose and treat psychiatric conditions.