Details

Autor(en) / Beteiligte

• Joste, Valentin
• Colard-Itté, Emma
• Guillochon, Émilie
• Ariey, Frédéric
• Coppée, Romain
• Clain, Jérôme
• Houzé, Sandrine

Titel

Genetic Profiling of Plasmodium ovale wallikeri Relapses With Microsatellite Markers and Whole-Genome Sequencing

Ist Teil von

• The Journal of infectious diseases, 2023-10, Vol.228 (8), p.1089-1098

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2023

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Like Plasmodium vivax, both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitemia originating from liver-dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of 8 highly polymorphic microsatellite markers, we genotyped 15 P ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the 4 relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P ovale spp. Using a novel set of 8 highly polymorphic microsatellite markers and whole-genome sequencing, we provide the first genetic evidence of relapses in Plasmodium ovale wallikeri.