Details

Autor(en) / Beteiligte

• Hamaguchi, Ayaka
• Fukuda, Hayato
• Fujiwara, Koichi
• Harada, Tomofumi
• Fukushima, Keijo
• Shuto, Satoshi
• Fujino, Hiromichi

Titel

Individual resolvin E family members work distinctly and in a coordinated manner in the resolution of inflammation

Ist Teil von

• Prostaglandins & other lipid mediators, 2023-10, Vol.168, p.106759-106759, Article 106759

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Three main E-type resolvins (RvEs): RvE1, RvE2, and RvE3, have roles in the resolution of inflammation as anti-inflammatory activities. To investigate the roles of each RvE in the resolution of inflammation, timing of interleukin (IL)− 10 release and IL-10 receptor expressions, and phagocytosis evoked by each RvE in differentiated human monocytes, macrophage-like U937 cells were examined. Here, we show that RvEs enhance the expression of IL-10, and IL-10 receptor-mediated signaling pathways and IL-10-mediated-signaling-independent resolution of inflammatory effects by activating the phagocytotic function. Thus, RvE2 mainly evoked an IL-10-mediated anti-inflammatory function, whereas RvE3 principally activated phagocytotic activity of macrophages, which may be involved in tissue repair. On the other hand, RvE1 showed both functions, although not prominent but rather acting as a relief mediator that takes over the RvE2 function and passes over to the RvE3 function. Therefore, each RvE may act as an important role/stage-specific mediator in a coordinated manner with other RvEs in the processes of the resolution of inflammation. •RvEs have roles in the attenuation of inflammation and tissue repair for resolution.•RvE2 mainly evoked an IL-10-mediated anti-inflammatory function.•RvE3 principally activated phagocytotic activity for tissue repair.•RvE1 showed both functions and acts as a relief mediator between RvE2 and RvE3.•Each RvE may play an important role/stage-specific mediator in a coordinated manner.