Details

Autor(en) / Beteiligte

• Yu, Zhi-Cheng
• Shen, Xi
• Zhou, You
• Ma, Jin-Tian
• Chen, Xiang-Long
• Wang, Li-Sheng
• Wu, Yan-Dong
• Wu, An-Xin

Titel

Successive Promotion of Formal [3+2] Cycloaddition of Aryl Methyl Ketones by I2 and Zn: Access to 2‑Hydroxy-4-morpholin-2,5-diarylfuran-3(2H)‑ones with a Quaternary Carbon Center

Ist Teil von

• Journal of organic chemistry, 2023-07, Vol.88 (13), p.9321-9331

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• 2-Hydroxy-4-morpholin-2,5-diarylfuran-3­(2H)-one derivatives were constructed sequentially using iodine and zinc dust from simple and readily available methyl ketone and morpholine as the starting materials. Under mild conditions, C–C, C–N, and C–O bonds formed in a one-pot synthesis. A quaternary carbon center was successfully constructed, and the active drug fragment morpholine was introduced into the molecule.