Details

Autor(en) / Beteiligte

• Bhattacharya, Sankha
• Parihar, Vipan Kumar
• Singh, Neeraj
• Hatware, Ketan
• Page, Amit
• Sharma, Mayank
• Prajapati, Mahendra Kumar
• Kanugo, Abhishek
• Pawde, Datta
• Maru, Saurabh
• Gupta, Girdhari Lal
• Kanvinde, Sunil

Titel

Targeted delivery of panitumumab-scaffold bosutinib-encapsulated polycaprolactone nanoparticles for EGFR-overexpressed colorectal cancer

Ist Teil von

• Nanomedicine (London, England), 2023-04, Vol.18 (9), p.713-741

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2023

Beschreibungen/Notizen

• Panitumumab (anti-Erb)-conjugated polycaprolactone (PCL) nanoparticles loaded with bosutinib (BTNB) were used to develop a targeted drug-delivery system for colon cancer cells. Using carbodiimide coupling, anti-Erb was conjugated to BTNB-loaded PCL nanoparticles. Dynamic light scattering, scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction and thermogravimetric analysis were used to analyze nanoparticles. According to studies, anti-Erb-BTNB-PCL nanoparticles inhibited HCT116 cells more than BTNB alone. Cell arrest at different phases was examined for apoptotic potential. An efficacy study showed that anti-Erb-BTNB-PCL nanoparticles could target tumors selectively. Anti-Erb-conjugated BTNB nanoparticles could specifically target colon cancer.