Details

Autor(en) / Beteiligte

• Wang, X H
• Wang, S Y
• Peng, H X
• Fan, M
• Guo, H D
• Hou, T J
• Wang, M Y
• Wu, Y Q
• Qin, X Y
• Tang, X
• Li, J
• Chen, D F
• Hu, Y H
• Wu, T

Titel

Genotype-environment interaction on arterial stiffness: A pedigree-based study

Ist Teil von

• Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2023-06, Vol.55 (3), p.400-407

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• To utilized the baseline data of the Beijing Fangshan Family Cohort Study, and to estimate whether the association between a healthy lifestyle and arterial stiffness might be modified by genetic effects. Probands and their relatives from 9 rural areas in Fangshan district, Beijing were included in this study. We developed a healthy lifestyle score based on five lifestyle behaviors: smoking, alcohol consumption, body mass index (BMI), dietary pattern, and physical activity. The measurements of arterial stiffness were brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). A variance component model was used to determine the heritability of arterial stiffness. Genotype-environment interaction effects were performed by the maximum likelihood methods. Subsequently, 45 candidate single nucleotide polymorphisms (SNPs) located in the glycolipid metabolism pathway were selected, and generalized estimated equations were used to assess the gene-environment interaction effects between particular genet