Details

Autor(en) / Beteiligte

• Cavalcante, L. B. C. P.
• Brandão, C. M. Á.
• Chiamolera, M. I.
• Biscolla, R. P. M.
• Junior, J. V. L.
• de Sá Tavares Russo, P.
• Morgado, J. P. M.
• de Francischi Ferrer, C. M. A.
• Vieira, J. G. H.

Titel

Big data-based parathyroid hormone (PTH) values emphasize need for age correction

Ist Teil von

• Journal of endocrinological investigation, 2023-12, Vol.46 (12), p.2525-2533

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose We aimed to study the relationship between aging and increased parathyroid hormone (PTH) values. Methods We performed a retrospective cross-sectional study with data from patients who underwent outpatient PTH measurements performed by a second-generation electrochemiluminescence immunoassay. We included patients over 18 years of age with simultaneous PTH, calcium, and creatinine measurements and 25-OHD measured within 30 days. Patients with glomerular filtration rate < 60 mL/min/1.73 m 2 , altered calcemia, 25-OHD level < 20 ng/mL, PTH values > 100 pg/mL or using lithium, furosemide or antiresorptive therapy were excluded. Statistical analyses were performed using the RefineR method. Results Our sample comprised 263,242 patients for the group with 25-OHD ≥ 20 ng/mL, that included 160,660 with 25-OHD ≥ 30 ng/mL. The difference in PTH values among age groups divided by decades was statistically significant (p < 0.0001), regardless of 25-OHD values, ≥ 20 or ≥ 30 ng/mL. In the group with 25-OHD ≥ 20 ng/mL and more than 60 years, the PTH values were 22.1–84.0 pg/mL, a different upper reference limit from the reference value recommended by the kit manufacturer. Conclusion We observed a correlation between aging and PTH increase, when measured by a second-generation immunoassay, regardless of vitamin D levels, if greater than 20 ng/mL, in normocalcemic individuals without renal dysfunction.