Details

Autor(en) / Beteiligte

• Goyette, Marie-Anne
• Lipsyc-Sharf, Marla
• Polyak, Kornelia

Titel

Clinical and translational relevance of intratumor heterogeneity

Ist Teil von

• Trends in Cancer, 2023-09, Vol.9 (9), p.726-737

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Intratumor heterogeneity (ITH) is a driver of tumor evolution and a main cause of therapeutic resistance. Despite its importance, measures of ITH are still not incorporated into clinical practice. Consequently, standard treatment is frequently ineffective for patients with heterogeneous tumors as changes to treatment regimens are made only after recurrence and disease progression. More effective combination therapies require a mechanistic understanding of ITH and ways to assess it in clinical samples. The growth of technologies enabling the spatially intact analysis of tumors at the single-cell level and the development of sophisticated preclinical models give us hope that ITH will not simply be used as a predictor of a poor outcome but will guide treatment decisions from diagnosis through treatment.