Details

Autor(en) / Beteiligte

• Holm, Mette Overgaard
• Bye, Asta
• Falkmer, Ursula
• Tobberup, Randi
• Rasmussen, Henrik Højgaard
• Lauridsen, Charlotte
• Yilmaz, Mette Karen
• Søndergaard, Jimmi
• Poulsen, Laurids Østergaard

Titel

The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer: A systematic review

Ist Teil von

• Critical reviews in oncology/hematology, 2023-08, Vol.188, p.104038-104038, Article 104038

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Acute radiation-induced diarrhoea (RID) is a well-known side effect of external radiation therapy for pelvic cancer. Acute RID is an unresolved clinical problem in approximately 80% of patients. We investigated the effect of nutritional interventions on acute RID in patients with pelvic cancer treated with curative radiotherapy. A search was conducted using PubMed, Embase.com, CINAHL, and Cochrane Library, from 1 January 2005 until 10 October 2022. We included randomised controlled trials or prospective observational studies. Eleven of the 21 identified studies had low quality of evidence, mainly because of low patient numbers distributed among several cancer diagnoses, and non-systematic assessment of acute RID. Interventions included probiotics (n = 6), prebiotics (n = 6), glutamine (n = 4), and others (n = 5). Five studies, of which two provided high quality evidence, showed that probiotics improved acute RID. Future well-designed studies investigating the effects of probiotics on acute RID are warranted. PROSPERO ID: CRD42020209499). [Display omitted] •Fifteen of the 21 included studies had a high risk of bias.•Clinical heterogeneity and non-systematic studies of RID make the main risk of bias.•Interventions with probiotics yield approvement of acute RID.