Details

Autor(en) / Beteiligte

• Spears, Richard J.
• Chudasama, Vijay

Titel

Recent advances in N- and C-terminus cysteine protein bioconjugation

Ist Teil von

• Current opinion in chemical biology, 2023-08, Vol.75, p.102306-102306, Article 102306

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Advances in the site-specific chemical modification of proteins, also referred to as protein bioconjugation, have proved instrumental in revolutionary approaches to designing new protein-based therapeutics. Of the sites available for protein modification, cysteine residues or the termini of proteins have proved especially popular owing to their favorable properties for site-specific modification. Strategies that, therefore, specifically target cysteine at the termini offer a combination of these favorable properties of cysteine and termini bioconjugation. In this review, we discuss these strategies with a particular focus on those reported recently and provide our opinion on the future direction of the field.