Details

Autor(en) / Beteiligte

• Burns, Andrew R.
• Baker, Rachel J.
• Kitner, Megan
• Knox, Jessica
• Cooke, Brittany
• Volpatti, Jonathan R.
• Vaidya, Aditya S.
• Puumala, Emily
• Palmeira, Bruna M.
• Redman, Elizabeth M.
• Snider, Jamie
• Marwah, Sagar
• Chung, Sai W.
• MacDonald, Margaret H.
• Tiefenbach, Jens
• Hu, Chun
• Xiao, Qi
• Finney, Constance A. M.
• Krause, Henry M.
• MacParland, Sonya A.
• Stagljar, Igor
• Gilleard, John S.
• Cowen, Leah E.
• Meyer, Susan L. F.
• Cutler, Sean R.
• Dowling, James J.
• Lautens, Mark
• Zasada, Inga
• Roy, Peter J.

Titel

Selective control of parasitic nematodes using bioactivated nematicides

Ist Teil von

• Nature (London), 2023-06, Vol.618 (7963), p.102-109

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Parasitic nematodes are a major threat to global food security, particularly as the world amasses 10 billion people amid limited arable land 1 – 4 . Most traditional nematicides have been banned owing to poor nematode selectivity, leaving farmers with inadequate means of pest control 4 – 12 . Here we use the model nematode Caenorhabditis elegans to identify a family of selective imidazothiazole nematicides, called selectivins, that undergo cytochrome-p450-mediated bioactivation in nematodes. At low parts-per-million concentrations, selectivins perform comparably well with commercial nematicides to control root infection by Meloidogyne incognita , a highly destructive plant-parasitic nematode. Tests against numerous phylogenetically diverse non-target systems demonstrate that selectivins are more nematode-selective than most marketed nematicides. Selectivins are first-in-class bioactivated nematode controls that provide efficacy and nematode selectivity. A metabolically bioactivated selective imidazothiazole nematicide shows comparable effectiveness at controlling plant root infection by Meloidogyne incognita to commercial nematicides, which are traditionally nonselective and toxic.