Details

Autor(en) / Beteiligte

• Hanff, Anne-Marie
• McCrum, Christopher
• Rauschenberger, Armin
• Aguayo, Gloria A.
• Zeegers, Maurice P.
• Leist, Anja K.
• Krüger, Rejko

Titel

Validation of a Parkinson's disease questionnaire-39-based functional mobility composite score (FMCS) in people with Parkinson's disease

Ist Teil von

• Parkinsonism & related disorders, 2023-07, Vol.112, p.105442-105442, Article 105442

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Functional mobility is an important outcome for people with Parkinson's disease (PwP). Despite this, there is no established patient-reported outcome measure that serves as a gold standard for assessing patient-reported functional mobility in PwP. We aimed to validate the algorithm calculating the Parkinson's Disease Questionnaire-39 (PDQ-39) based Functional Mobility Composite Score (FMCS). We designed a count-based algorithm to measure patient-reported functional mobility in PwP from items of the PDQ-39 subscales mobility and activities of daily living. Convergent validity of the algorithm calculating the PDQ-39-based FMCS was assessed using the objective Timed Up and Go (n = 253) and discriminative validity was assessed by comparing the FMCS with patient-reported (MDS-UPDRS II) and clinician-assessed (MDS-UPDRS III) motor symptoms as well as between disease stages (H&Y) and PIGD phenotypes (n = 736). Participants were between 22 and 92 years old, with a disease duration from 0 to 32 years and 64.9% in a H&Y 1–2 ranging from 1 to 5. Spearman correlation coefficients (rs) ranging from −0.45 to −0.77 (p < 0.001) indicated convergent validity. Hence, a t-test suggested sufficient ability of the FMCS to discriminate (p < 0.001) between patient-reported and clinician-assessed motor symptoms. More specifically, FMCS was more strongly associated with patient-reported MDS-UPDRS II (rs = −0.77) than clinician-reported MDS-UPDRS III (rs = −0.45) and can discriminate between disease stages as between PIGD phenotypes (p < 0.001). The FMCS is a valid composite score to assess functional mobility through patient reports in PwP for studying functional mobility in studies using the PDQ-39. •The PDQ-39-based functional mobility composite score (FMCS) is a valid measure of patient-reported FM.•The algorithm allows a retrospective analysis PDQ-39 data in clinical and research settings.•The R-shiny app and scores by various subgroups aim to enhanceclinical interpretation.