Details

Autor(en) / Beteiligte

• Armstrong, Jane F.
• Campo, Brice
• Alexander, Stephen P. H.
• Arendse, Lauren B.
• Cheng, Xiu
• Davenport, Anthony P.
• Faccenda, Elena
• Fidock, David A.
• Godinez‐Macias, Karla P.
• Harding, Simon D.
• Kato, Nobutaka
• Lee, Marcus C. S.
• Luth, Madeline R.
• Mazitschek, Ralph
• Mittal, Nimisha
• Niles, Jacquin C.
• Okombo, John
• Ottilie, Sabine
• Pasaje, Charisse Flerida A.
• Probst, Alexandra S.
• Rawat, Mukul
• Rocamora, Frances
• Sakata‐Kato, Tomoyo
• Southan, Christopher
• Spedding, Michael
• Tye, Mark A.
• Yang, Tuo
• Zhao, Na
• Davies, Jamie A.

Titel

Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Ist Teil von

• British journal of pharmacology, 2023-08, Vol.180 (15), p.1899-1929

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target‐based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.