Details

Autor(en) / Beteiligte

• Xu, Ling‐Wen
• Zhang, Xue‐Qian
• Yan, Zheng
• Li, Zhi‐Hong
• Deng, An‐Jun
• Qin, Hai‐Lin

Titel

Synthesis and Cytotoxicity Assessment against Human Colorectal Cancer Cell Lines of Quaternary 8‐Dichloromethyl Protoberberine Alkaloids

Ist Teil von

• Chemistry & biodiversity, 2023-06, Vol.20 (6), p.e202300570-n/a

Ort / Verlag

Switzerland: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Twenty‐two quaternary 8‐dichloromethylprotoberberine alkaloids were synthesized from unmodified quaternary protoberberine alkaloids (QPAs) to improve their physical and chemical properties and to obtain selectively anticancer derivatives. The synthesized derivatives showed more appropriate octanol/water partition coefficients by up to values 3–4 compared to unmodified QPA substrates. In addition, these compounds exhibited significant antiproliferative activity against colorectal cancer cells and lower toxicity on normal cells, resulting in more significant selectivity indices than unmodified QPA compounds in vitro. The IC50 values of antiproliferative activity of quaternary 8‐dichloromethyl‐pseudoberberine 4‐chlorobenzenesulfonate and quaternary 8‐dichloromethyl‐pseudopalmatine methanesulfonate against colorectal cancer cells are 0.31 μM and 0.41 μM, respectively, significantly stronger than those of other compounds and positive control 5‐fluorouracil. These findings suggest that 8‐dichloromethylation can be used as one of the modification strategies to guide the structural modification and subsequent investigation of anticancer drugs for CRC based on QPAs.