Details

Autor(en) / Beteiligte

• Namusobya, Martha
• Bongomin, Felix
• Mukisa, John
• Batte, Charles
• Olwit, William Kane
• Rhein, Joshua
• Sekaggya-Wiltshire, Christine
• Prasad, Shailendra

Titel

The Impact of Chronic Pulmonary Aspergillosis Co-infection on the Health-Related Quality of Life of Patients with Pulmonary Tuberculosis in Uganda

Ist Teil von

• Mycopathologia (1975), 2023-10, Vol.188 (5), p.713-720

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2023

Quelle

Springer Nature - Complete Springer Journals

Beschreibungen/Notizen

• Background Both pulmonary tuberculosis (PTB) and chronic pulmonary aspergillosis (CPA) significantly affect health-related quality of life (HR-QoL). We aimed to determine the impact of CPA co-infection on the HR-QoL of Ugandans with PTB. Methods We conducted a prospective study as part of a larger study among participants with PTB with persistent pulmonary symptoms after 2 months of anti-TB treatment at Mulago Hospital, Kampala, Uganda between July 2020 and June 2021. HR-QoL was assessed using St. George Respiratory Questionnaire (SGRQ) at enrollment and at the end of PTB treatment (4 months apart). SGRQ scores range from 0 to 100, with higher score representing a poorer HR-QoL. Results Of the 162 participants enrolled in the larger study, 32 (19.8%) had PTB + CPA and 130 (80.2%) had PTB. The baseline characteristics of the two groups were comparable. Regarding overall health, a higher proportion of the PTB group rated their HR-QoL as “very good” compared to those who had PTB + CPA (68 [54.0%] versus 8 [25.8%]). At enrollment, both groups had comparable median SGRQ scores. However, at follow up, the PTB group had statistically significantly better SGRQ scores (interquartile range); symptoms (0 [0–12.4] versus 14.4 [0–42.9], p < 0.001), activity ((0 [0–17.1] versus 12.2 [0–35.5], p  = .03), impact (0 [0–4.0] versus 3.1 [0–22.5], p  = 0.004), and total scores ((0 [0–8.5] versus 7.6[(0–27.4], p  = 0.005). Conclusion CPA co-infection impairs HR-QoL of people with PTB. Active screening and management of CPA in patients with PTB is recommended to improve HR-QoL of these individuals.